Lyons and Yosco were an American comedy duo, consisting of Italian American musicians George Lyons and Bob Yosco. They were defined by the Ottawa Evening Journal "the finest pair of Italian street musicians playing in the Vaudeville ranks." They toured the United States from 1909 into 1923, doing a musical and comedy act. The News Journal described their performance, saying they were "the best vocalists and instrumentalists of the street variety on the stage, proved intensely interesting, while their droll comedy kept the audience laughing much of the time."

They were also successful composers of popular music, including ragtime. One of their best known works was the million-selling ragtime piece, "Spaghetti Rag" which was notably popular during the ragtime revival in the 1950s. Their compositions were recorded by performers for Victor Records and Columbia Records.

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